[PDF][PDF] PD-1 is involved in the dysregulation of type 2 innate lymphoid cells in a murine model of obesity

G Oldenhove, E Boucquey, A Taquin, V Acolty… - Cell reports, 2018 - cell.com
Recent observations clearly highlight the critical role of type 2 innate lymphoid cells in
maintaining the homeostasis of adipose tissues in humans and mice. This cell population …

PHD2 Constrains Antitumor CD8+ T-cell Activity

C Bisilliat Donnet, V Acolty, A Azouz, A Taquin… - Cancer immunology …, 2023 - AACR
The prolyl hydroxylase domain/hypoxia-inducible factor (PHD/HIF) pathway has been
implicated in a wide range of immune and inflammatory processes, including in the oxygen-…

[PDF][PDF] The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis

K Englebert, A Taquin, A Azouz, V Acolty, SV Velde… - Cell Reports, 2024 - cell.com
Adipose tissue homeostasis relies on the interplay between several regulatory lineages,
such as type 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, regulatory T cells, …

The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells

Y Ajouaou, A Azouz, A Taquin, S Denanglaire… - Elife, 2022 - elifesciences.org
The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia
adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) in numerous cell …

[HTML][HTML] A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

R Petkantchin, A Rousseau, O Eker… - Scientific reports, 2023 - nature.com
One of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a
biochemical product into the patient’s bloodstream, which breaks down the thrombi’s fibrin fibers: …

Star formation: Dynamical study of interstellar dust

U Lebreuilly - 2020 - theses.hal.science
… Merci `a mes deux fr`eres, José et Marin, même si on est taquins je dois vous le dire que j’aime
énormément vous retrouver pendant les vacances, c’est un bol d’air frais pour moi. Cela …

pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner

J Guo, AA Chakraborty, P Liu, W Gan, X Zheng… - Science, 2016 - science.org
Activation of the serine-threonine kinase Akt promotes the survival and proliferation of various
cancers. Hypoxia promotes the resistance of tumor cells to specific therapies. We therefore …

Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function

G Notarangelo, JB Spinelli, EM Perez, GJ Baker… - Science, 2022 - science.org
Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …

[BOOK][B] Les Passeurs de vérité

I Roche-Camus - 2021 - books.google.com
Sur la pointe bretonne, Chloé connaît un échec cuisant lors de sa première régate importante.
Alors que la jeune monitrice de voile rumine sa défaite, les vagues déposent à ses pieds …

Beau Coucou

JC Poulet - Beau Coucou, 2021 - torrossa.com
«Les oiseaux ont, dans la rétine, quatre types de cellules sensibles à la couleur, connues
sous le nom de cônes, tandis que les humains n’en ont que trois. Ce cône supplémentaire est …