Objectives To develop a rapid and reliable tool to detect by multiplex PCR assays the most
frequently widespread β-lactamase genes encoding the OXA-1-like broad-spectrum β-…

The cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ) is an important factor determining the
functional state of blood-brain barrier (BBB) endothelial cells but little is known on the effect of …

The present study was performed in an attempt to develop an in vitro integrated testing
strategy (ITS) to evaluate drug-induced neurotoxicity. A number of endpoints were analyzed …

Background. Intestinal carriage is a key factor in extended-spectrum β-lactamase (ESBL)
infection epidemiology but is difficult to study in open communities. To overcome this problem, …

The intracellular calcium concentration ([Ca 2+ ] i ) is an important factor determining the
permeability of endothelial barriers including the blood–brain barrier (BBB). However, nothing …

TFEB is a mammalian transcription factor that binds directly to the CLEAR consensus
sequence (5′‐GTCACGTGAC‐3′) present in the regulatory regions of genes inducing …

The biomedical applications of antibody engineering are developing rapidly and have been
expanded to plant expression platforms. In this study, we have generated a novel antibody …

In vertebrates, intercellular communication is largely mediated by connexins (Cx), a family
of structurally related transmembrane proteins that assemble to form hemichannels (HCs) at …

The early screening of nervous system medicines on a pertinent and reliable in cellulo BBB
model for their penetration and their interaction with the barrier and the brain parenchyma is …

Autophagy is a process leading to the degradation of cellular material, in organelles called
lysosomes, to supply energy or generate building blocks for the synthesis of new materials. …