Neutrophils are implicated in multiple homeostatic and pathological processes, but whether
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-…

CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable
proportion of human neutrophils that mediates surface expression of the antineutrophil …

IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …

Polyclonal CD8 + T cells, with a marked innate/memory phenotype, high eomesodermin (Eomes)
expression, and the capacity to generate IFN‐γ rapidly without prior exposure to …

Rheumatoid arthritis is a systemic autoimmune disease, but disease flares typically affect
only a subset of joints, distributed in a distinctive pattern for each patient. Pursuing this …

… Author links open overlay panel Mayte Suárez-Fariñas 1 2 ∗ , Minami Tokuyama 3 4 ∗ ,
Gabrielle Wei 2 5 , Ruiqi Huang 1 2 , Alexandra Livanos 3 4 , Divya Jha 3 4 , Anais Levescot 6 7 …

Still’s disease is a severe inflammatory syndrome characterized by fever, skin rash and arthritis
affecting children and adults. Patients with Still’s disease may also develop macrophage …

Although it is generally acknowledged that cytokines regulate normal hematopoiesis in an
autocrine/paracrine fashion, their possible role in chronic myelogenous leukemia (CML) and …

Coeliac disease (CD) is a frequent immune enteropathy induced by gluten in genetically
predisposed individuals. Its pathogenesis has been extensively studied and CD has emerged …

Background Studies on human genetic factors associated with malaria have hitherto
concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no …