Towards utilization of the human genome and microbiome for personalized nutrition
Highlights • People feature individualized glycemic responses to identical foods. • Genome
and microbiome data may explain individualized clinical features. • Personalized algorithms …
and microbiome data may explain individualized clinical features. • Personalized algorithms …
Environment dominates over host genetics in shaping human gut microbiota
Human gut microbiome composition is shaped by multiple factors but the relative contribution
of host genetics remains elusive. Here we examine genotype and microbiome data from …
of host genetics remains elusive. Here we examine genotype and microbiome data from …
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …
Structural variation in the gut microbiome associates with host health
Differences in the presence of even a few genes between otherwise identical bacterial
strains may result in critical phenotypic differences. Here we systematically identify microbial …
strains may result in critical phenotypic differences. Here we systematically identify microbial …
Diversity and functional landscapes in the microbiota of animals in the wild
…, N Raab, Y Pinto, D Rothschild, G Zanir, A Godneva… - Science, 2021 - science.org
Animals in the wild are able to subsist on pathogen-infected and poisonous food and show
immunity to various diseases. These may be due to their microbiota, yet we have a poor …
immunity to various diseases. These may be due to their microbiota, yet we have a poor …
Bacterial SNPs in the human gut microbiome associate with host BMI
Genome-wide association studies (GWASs) have provided numerous associations between
human single-nucleotide polymorphisms (SNPs) and health traits. Likewise, metagenome-…
human single-nucleotide polymorphisms (SNPs) and health traits. Likewise, metagenome-…
Personalized postprandial glucose response–targeting diet versus mediterranean diet for glycemic control in prediabetes
O Ben-Yacov, A Godneva, M Rein, S Shilo… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE To compare the clinical effects of a personalized postprandial-targeting (PPT)
diet versus a Mediterranean (MED) diet on glycemic control and metabolic health in …
diet versus a Mediterranean (MED) diet on glycemic control and metabolic health in …
Use of faecal transplantation with a novel diet for mild to moderate active ulcerative colitis: the craft UC randomised controlled trial
…, G Quaranta, N Kolonimos, A Godneva… - Journal of Crohn's …, 2022 - academic.oup.com
Background We evaluated whether integration of novel diets for donors and patients, in
addition to faecal transplantation [FT], could increase FT remission rate in refractory ulcerative …
addition to faecal transplantation [FT], could increase FT remission rate in refractory ulcerative …
Effect of a personalized diet to reduce postprandial glycemic response vs a low-fat diet on weight loss in adults with abnormal glucose metabolism and obesity: a …
…, A Schoenthaler, E Segal, A Godneva… - JAMA network …, 2022 - jamanetwork.com
Importance Interindividual variability in postprandial glycemic response (PPGR) to the same
foods may explain why low glycemic index or load and low-carbohydrate diet interventions …
foods may explain why low glycemic index or load and low-carbohydrate diet interventions …
The gut microbiome of adults with type 1 diabetes and its association with the host glycemic control
OBJECTIVE Previous studies have demonstrated an association between gut microbiota
composition and type 1 diabetes (T1D) pathogenesis. However, little is known about the …
composition and type 1 diabetes (T1D) pathogenesis. However, little is known about the …