Mutations in genes encoding subunits of the cohesin complex are common in several cancers,
but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines …

Developmental programs that arrange cells and tissues into patterned organs are remarkably
robust. In the developing vertebrate retina, for example, neurons reproducibly assemble …

Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3, and Rad21, and
either Stag1 or Stag2. Normal haematopoietic development relies on crucial functions of …

Niches have traditionally been characterised as signalling microenvironments that allow stem
cells to maintain their fate. This definition implicitly assumes that the various niche signals …

In recent years, remarkable progress has been made toward understanding the three-dimensional
(3D) organisation of genomes and the influence of genome organisation on gene …

Cohesin is a multi-subunit protein with roles in both cell division and gene expression. It
comprises three core subunits: Smc1a, Smc3 and Rad21, which form a ring-shaped complex …

The cholesterol hydroxylase/lyase (CHL) system, consisting of cytochrome P450scc,
adrenodoxin (Adx) and adrenodoxin reductase (AdR), initiates mammalian steroidogenesis, …

Cohesin, a chromatin-associated protein complex with four core subunits (Smc1a, Smc3,
Rad21 and either Stag1 or 2), has a central role in cell proliferation and gene expression in …

Developmental programs that arrange cells and tissues into patterned organs are remarkably
robust. In the developing vertebrate retina for example, neurons reproducibly assemble …

… We thank the members of our laboratory, especially Anastasia Labudina, for helpful …
Ketharnathan, S.; Labudina, A.; Horsfield, JA Cohesin Components Stag1 and Stag2 Differentially …