YB‐1 is a DNA/RNA‐binding nucleocytoplasmic shuttling protein whose regulatory effect on
many DNA‐ and RNA‐dependent events is determined by its localization in the cell. …

HIV-1 reverse transcription (RT) occurs before or during uncoating, but the cellular compartment
where RT and uncoating occurs is unknown. Using imaging and biochemical assays to …

Disruption of cyclophilin A (CypA)-capsid interactions affects HIV-1 replication in human
lymphocytes. To understand this mechanism, we utilize human Jurkat cells, peripheral blood …

The Y-box binding protein 1 (YB-1) is a DNA/RNA-binding nucleocytoplasmic shuttling protein
whose regulatory effect on many DNA and RNA-dependent events is determined by its …

SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and
the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (…

The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207).
We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection. HIV-1 …

SERINC5(S5) is a multi-span transmembrane protein that potently blocks the infectivity of
HIV-1 produced by human T-cells. The ability of S5 to restrict infectivity correlates with its …

The antiretroviral activity of azulene derivatives was detected for the first time. A series of
eighteen diversely substituted azulenes was synthesized and tested in vitro using HIV-1 based …

A set of top-ranked compounds from a multi-objective in silico screen was experimentally
tested for toxicity and the ability to inhibit the activity of HIV-1 reverse transcriptase (RT) in cell-…

The capsid-binding assay is an in vitro experiment used to determine whether cellular proteins
interact with the HIV-1 core. In vitro assembled HIV-1 capsids recapitulate the surface of …