A poorly understood aspect of bone biomineralization concerns the mechanisms whereby
ions are sequestered from the environment, concentrated, and deposited in the extracellular …

Many important biological questions can be addressed by studying in 3D large volumes of
intact, cryo fixed hydrated tissues (⩾10,000 μm 3 ) at high resolution (5–20 nm). This can be …

Bone formation (osteogenesis) is a complex process in which cellular differentiation and the
generation of a mineralized organic matrix are synchronized to produce a hybrid …

The uptake and transport of ions from the environment to the site of bone formation is only
partially understood and, for the most part, based on disparate observations in different …

Traditionally, bone tissue engineering has been used for creating implants for bone
regeneration, but recently, it is increasingly applied to create three-dimensional (3D) in vitro bone …

Aragonite skeletons in corals are key contributors to the storage of atmospheric CO 2
worldwide. Hence, understanding coral biomineralization/calcification processes is crucial for …

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether
this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney …

Many biomineral crystals form complex non-equilibrium shapes, often via transient amorphous
precursors. Also in vitro crystals can be grown with non-equilibrium morphologies, such …

Both in vivo and ex vivo observations support the hypothesis that bone mineral formation
proceeds via disordered precursor phases. The characteristics of the precursor phases are not …

The mineralized collagen fibril is the basic building block of bone, and is commonly pictured
as a parallel array of ultrathin carbonated hydroxyapatite (HAp) platelets distributed …