Gut microbiome pattern reflects healthy ageing and predicts survival in humans
The gut microbiome has important effects on human health, yet its importance in human
ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late …
ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late …
[HTML][HTML] Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention
Multiomic profiling can reveal population heterogeneity for both health and disease states.
Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic …
Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic …
Prediction of multidimensional drug dose responses based on measurements of drug pairs
A Zimmer, I Katzir, E Dekel… - Proceedings of the …, 2016 - National Acad Sciences
Finding potent multidrug combinations against cancer and infections is a pressing
therapeutic challenge; however, screening all combinations is difficult because the number of …
therapeutic challenge; however, screening all combinations is difficult because the number of …
[HTML][HTML] Promoter activity dynamics in the lag phase of Escherichia coli
D Madar, E Dekel, A Bren, A Zimmer, Z Porat… - BMC systems …, 2013 - Springer
Background Lag phase is a period of time with no growth that occurs when stationary phase
bacteria are transferred to a fresh medium. Bacteria in lag phase seem inert: their biomass …
bacteria are transferred to a fresh medium. Bacteria in lag phase seem inert: their biomass …
[HTML][HTML] A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA
…, KA Collier, ACH Hoge, K Chen, A Zimmer… - Nature …, 2022 - nature.com
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide
clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome …
clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome …
[HTML][HTML] Tumor diversity and the trade-off between universal cancer tasks
Recent advances have enabled powerful methods to sort tumors into prognosis and treatment
groups. We are still missing, however, a general theoretical framework to understand the …
groups. We are still missing, however, a general theoretical framework to understand the …
[HTML][HTML] Prediction of drug cocktail effects when the number of measurements is limited
Cocktails of drugs can be more effective than single drugs, because they can potentially
work at lower doses and avoid resistance. However, it is impossible to test all drug cocktails …
work at lower doses and avoid resistance. However, it is impossible to test all drug cocktails …
[HTML][HTML] The geometry of clinical labs and wellness states from deeply phenotyped humans
Longitudinal multi-omics measurements are highly valuable in studying heterogeneity in
health and disease phenotypes. For thousands of people, we have collected longitudinal multi-…
health and disease phenotypes. For thousands of people, we have collected longitudinal multi-…
[HTML][HTML] DNA-based copy number analysis confirms genomic evolution of PDX models
ACH Hoge, M Getz, A Zimmer, M Ko, L Raz… - NPJ Precision …, 2022 - nature.com
Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence
away of their tumors of origin. We previously reported the genomic evolution of the copy …
away of their tumors of origin. We previously reported the genomic evolution of the copy …
Dynamic proteomics of herpes simplex virus infection
…, A Mayo, T Danon, L Shapira, D Rafael, A Zimmer… - MBio, 2017 - Am Soc Microbiol
The cellular response to viral infection is usually studied at the level of cell populations.
Currently, it remains an open question whether and to what extent cell-to-cell variability impacts …
Currently, it remains an open question whether and to what extent cell-to-cell variability impacts …