Antibacterial resistance is a great concern and requires global action. A critical question is
whether enough new antibacterial drugs are being discovered and developed. A review of the …

The effective permeability (P eff ) in the human jejunum (in vivo) of 22 structurally diverse
compounds was correlated with both experimentally determined lipophilicity values and …

Antibiotics are the medical wonder of our age, but an increasing frequency of resistance among
key pathogens is rendering them less effective. If this trend continues the consequences …

Antibiotic resistance (ABR) is a global public health threat. Despite the emergence of highly
resistant organisms and the huge medical need for new drugs, the development of …

The first druglike selective angiotensin II AT 2 receptor agonist (21) with a K i value of 0.4 nM
for the AT 2 receptor and a K i >10 μM for the AT 1 receptor is reported. Compound 21, with …

The interaction between HIV-1 protease and 58 structurally diverse transition-state
analogue inhibitors has been analyzed by a surface plasmon resonance based biosensor. …

Two cyclic, C 2 -symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative,
both comprising phenyl ether groups in the P1/P1‘ positions, were cocrystallized with HIV-1 …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused
by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to …

Ten C 2 -symmetric cyclic urea and sulfamide derivatives have been synthesized from l-mannonic
γ-lactone and d-mannitol. The results of experimental measurement of their inhibitory …

Vinyl sulfide cyclized analogues of the octapeptide angiotensin II that are structurally related
to the cyclic disulfide agonist c[Hcy 3,5 ]Ang II have been prepared. The synthesis relies on …