[HTML][HTML] Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2′-O-methylation by nsp16/nsp10 protein complex

Y Chen, C Su, M Ke, X Jin, L Xu, Z Zhang, A Wu… - PLoS …, 2011 - journals.plos.org
The 5′-cap structure is a distinct feature of eukaryotic mRNAs, and eukaryotic viruses
generally modify the 5′-end of viral RNAs to mimic cellular mRNA structure, which is important …

Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis

Y Wang, Y Sun, A Wu, S Xu, R Pan, C Zeng… - Journal of …, 2015 - Am Soc Microbiol
The 5′ cap structures of eukaryotic mRNAs are important for RNA stability and protein
translation. Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-…

Vascular Aging: Assessment and Intervention

…, Z Yu, S Tian, AH Khan, Y Zhu, A Wu… - … Interventions in Aging, 2023 - Taylor & Francis
Vascular aging represents a collection of structural and functional changes in a blood
vessel with advancing age, including increased stiffness, vascular wall remodeling, loss of …

Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase

…, Y Sun, A Wu, C Su, G Gao, H Cai, S Qiu, Y Wu… - Journal of …, 2013 - Am Soc Microbiol
Coronaviruses possess a cap structure at the 5′ ends of viral genomic RNA and subgenomic
RNAs, which is generated through consecutive methylations by virally encoded guanine-…

Mo-doped SnO2 nanotubes sensor with abundant oxygen vacancies for ethanol detection

L Wang, S Ma, J Li, A Wu, D Luo, T Yang, P Cao… - Sensors and Actuators B …, 2021 - Elsevier
This work describes a synthesizing method for Mo-doped SnO 2 nanotubes (NTs) with uniform
morphology by combining electrostatic spinning and air sintering. The method uses Mo …

Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10 …

M Ke, Y Chen, A Wu, Y Sun, C Su, H Wu, X Jin, J Tao… - Virus research, 2012 - Elsevier
Coronaviruses are the etiological agents of respiratory and enteric diseases in humans and
livestock, exemplified by the life-threatening severe acute respiratory syndrome (SARS) …

Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP

X Jin, Y Chen, Y Sun, C Zeng, Y Wang, J Tao, A Wu… - Virus research, 2013 - Elsevier
Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved
strategies to cap their RNAs. In our previous work, the nonstructural protein (nsp) 14 of …

[HTML][HTML] Hyperglycemia promotes endothelial cell senescence through AQR/PLAU signaling axis

Y Wan, Z Liu, A Wu, AH Khan, Y Zhu, S Ding… - International Journal of …, 2022 - mdpi.com
Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to
diabetic complications. The underlying mechanism, however, remains elusive. We previously …

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

A Wu, YI Wang, C Zeng, X Huang, S Xu, C Su, M Wang… - Virus research, 2015 - Elsevier
Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral
polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4–16. …

Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase

Y Sun, Z Wang, J Tao, Y Wang, A Wu, Z Yang, K Wang… - Antiviral research, 2014 - Elsevier
The 5′-cap structure is a distinct feature of eukaryotic mRNAs and is important for RNA
stability and protein translation by providing a molecular signature for the distinction of self or …