[HTML][HTML] Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2′-O-methylation by nsp16/nsp10 protein complex
Y Chen, C Su, M Ke, X Jin, L Xu, Z Zhang, A Wu… - PLoS …, 2011 - journals.plos.org
The 5′-cap structure is a distinct feature of eukaryotic mRNAs, and eukaryotic viruses
generally modify the 5′-end of viral RNAs to mimic cellular mRNA structure, which is important …
generally modify the 5′-end of viral RNAs to mimic cellular mRNA structure, which is important …
Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis
The 5′ cap structures of eukaryotic mRNAs are important for RNA stability and protein
translation. Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-…
translation. Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-…
Vascular Aging: Assessment and Intervention
…, Z Yu, S Tian, AH Khan, Y Zhu, A Wu… - … Interventions in Aging, 2023 - Taylor & Francis
Vascular aging represents a collection of structural and functional changes in a blood
vessel with advancing age, including increased stiffness, vascular wall remodeling, loss of …
vessel with advancing age, including increased stiffness, vascular wall remodeling, loss of …
Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase
…, Y Sun, A Wu, C Su, G Gao, H Cai, S Qiu, Y Wu… - Journal of …, 2013 - Am Soc Microbiol
Coronaviruses possess a cap structure at the 5′ ends of viral genomic RNA and subgenomic
RNAs, which is generated through consecutive methylations by virally encoded guanine-…
RNAs, which is generated through consecutive methylations by virally encoded guanine-…
Mo-doped SnO2 nanotubes sensor with abundant oxygen vacancies for ethanol detection
L Wang, S Ma, J Li, A Wu, D Luo, T Yang, P Cao… - Sensors and Actuators B …, 2021 - Elsevier
This work describes a synthesizing method for Mo-doped SnO 2 nanotubes (NTs) with uniform
morphology by combining electrostatic spinning and air sintering. The method uses Mo …
morphology by combining electrostatic spinning and air sintering. The method uses Mo …
Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10 …
M Ke, Y Chen, A Wu, Y Sun, C Su, H Wu, X Jin, J Tao… - Virus research, 2012 - Elsevier
Coronaviruses are the etiological agents of respiratory and enteric diseases in humans and
livestock, exemplified by the life-threatening severe acute respiratory syndrome (SARS) …
livestock, exemplified by the life-threatening severe acute respiratory syndrome (SARS) …
Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
X Jin, Y Chen, Y Sun, C Zeng, Y Wang, J Tao, A Wu… - Virus research, 2013 - Elsevier
Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved
strategies to cap their RNAs. In our previous work, the nonstructural protein (nsp) 14 of …
strategies to cap their RNAs. In our previous work, the nonstructural protein (nsp) 14 of …
[HTML][HTML] Hyperglycemia promotes endothelial cell senescence through AQR/PLAU signaling axis
Y Wan, Z Liu, A Wu, AH Khan, Y Zhu, S Ding… - International Journal of …, 2022 - mdpi.com
Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to
diabetic complications. The underlying mechanism, however, remains elusive. We previously …
diabetic complications. The underlying mechanism, however, remains elusive. We previously …
Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
A Wu, YI Wang, C Zeng, X Huang, S Xu, C Su, M Wang… - Virus research, 2015 - Elsevier
Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral
polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4–16. …
polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4–16. …
Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase
Y Sun, Z Wang, J Tao, Y Wang, A Wu, Z Yang, K Wang… - Antiviral research, 2014 - Elsevier
The 5′-cap structure is a distinct feature of eukaryotic mRNAs and is important for RNA
stability and protein translation by providing a molecular signature for the distinction of self or …
stability and protein translation by providing a molecular signature for the distinction of self or …