Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, …

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence variability
1 . Many studies suggest that mtDNA variants may be associated with ageing or diseases 2 …

While the initial pathology of Parkinson’s disease and other α‐synucleinopathies is often
confined to circumscribed brain regions, it can spread and progressively affect adjacent and …

Heart failure (HF) is a major health and economic burden in developed countries. It has been
proposed that the pathogenesis of HF may involve the action of mitochondria. We evaluate …

Eosinophils are able to secrete exosomes that have an undefined role in asthma pathogenesis.
We hypothesized that exosomes released by eosinophils autoregulate and promote …

Aims Short QT syndrome type 3 (SQTS3) is a rare arrhythmogenic disease caused by gain-of-function
mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2.1…

N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used
as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity …

The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is
caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion …

Aims The transcription factor Tbx5 controls cardiogenesis and drives Scn5a expression in
mice. We have identified two variants in TBX5 encoding p. D111Y and p. F206L Tbx5, …

The continuous relationship between blood pressure (BP) and cardiovascular events makes
the distinction between elevated BP and hypertension based on arbitrary cut-off values for …