Predicting antibiotic efficacy within microbial communities remains highly challenging.
Interspecies interactions can impact antibiotic activity through many mechanisms, including …

Mechanistic understanding of the impacts of the gut microbiota on human health has been
hampered by limited throughput in animal models. To enable systematic interrogation of gut-…

The spatiotemporal structure of the human microbiome 1 , 2 , proteome 3 and metabolome
4 , 5 reflects and determines regional intestinal physiology and may have implications for …

Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector
is now firmly established in urban settings in the Horn of Africa. Its presence in areas where …

Efforts to model the human gut microbiome in mice have led to important insights into the
mechanisms of host-microbe interactions. However, the model communities studied to date …

Antibiotics alter microbiota composition and increase infection susceptibility. However, the
generalizable effects of antibiotics on and the contribution of environmental variables to gut …

Efforts to probe the role of the gut microbiota in disease would benefit from a system in
which patient-derived bacterial communities can be studied at scale. We addressed this by …

The gut is continuously invaded by diverse bacteria from the diet and the environment, yet
microbiome composition is relatively stable over time for host species ranging from mammals …

10.7554/eLife.11878.001 The membrane-bound transcription factor ATF6α plays a cytoprotective
role in the unfolded protein response (UPR), required for cells to survive ER stress. …

… Jessica Fields, J Raul Gutierrez, Carina Marquez, Kim Rhoads, Margot Kushel, Alicia
Fernandez, Gabriel Chamie, Francine Rios-Fetchko, Elizabeth Imbert, Cynthia Nagendra …