The study of animal behaviour, ethology, is becoming more quantitative. New theory is
emerging, driven by better imaging and novel representations of animal posture dynamics …

Tissue cells lack the ability to see or hear but have evolved mechanisms to feel into their
surroundings and sense a collective stiffness. A cell can even sense the effective stiffness of …

Blood clots and thrombi consist primarily of a mesh of branched fibers made of the protein
fibrin. We propose a molecular basis for the marked extensibility and negative compressibility …

Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid
substitutions, or four with reassortment, might be sufficient for mammal-to-mammal transmission …

Using low-cost automated tracking microscopes, we have generated a behavioral database
for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described …

Visible phenotypes based on locomotion and posture have played a critical role in
understanding the molecular basis of behavior and development in Caenorhabditis elegans and …

Physical factors drive evolution and play important roles in motility and attachment as well
as in differentiation. As animal cells adhere to survive, they generate force and ‘feel' various …

Fibrinogen is a blood plasma protein that, after activation by thrombin, assembles into fibrin
fibers that form the elastic network of blood clots. We used atomic force microscopy to study …

Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the
accuracy of translation, yet the physiological consequence of having fewer protein synthesis …

We study the role of microtubule movement in bidirectional organelle transport in Drosophila
S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of …