The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …

Allosteric communication between distant sites in proteins is central to biological regulation
but still poorly characterized, limiting understanding, engineering and drug development 1 , …

Chromosome conformation capture approaches have shown that interphase chromatin is
partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological …

The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent
manner by colocalizing with master regulators at tissue-specific loci. The regulation of …

Prestellar cores form from the contraction of cold gas and dust material in dark clouds
before they collapse to form protostars. Several concurrent theories exist to describe this …

Dialysis patients exhibit an inverse, L- or U-shaped association between blood pressure
and mortality risk, in contrast to the linear association in the general population. We …

Variation in growth performances was analysed in 16 half-sib diploid and triploid families (from
different sires) of rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta). At …

In addition to mediating sister chromatid cohesion during the cell cycle, the cohesin
complex associates with CTCF and with active gene regulatory elements to form long-range …

Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For
example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS)…

10.7554/eLife.02626.001 As exome sequencing gives way to genome sequencing, the need
to interpret the function of regulatory DNA becomes increasingly important. To test whether …