User profiles for Andre Franke
 | Andre FrankeProfessor for Molecular Medicine, Christian-Albrechts-University of Kiel Verified email at mucosa.de Cited by 93670 |
[HTML][HTML] The dynamic genome of Hydra
The freshwater cnidarian Hydra was first described in 1702 1 and has been the object of
study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the …
study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Large-scale association analyses identify host factors influencing human gut microbiome composition
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
Microbial exposure during early life has persistent effects on natural killer T cell function
Exposure to microbes during early childhood is associated with protection from immune-mediated
diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show that …
diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show that …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
[HTML][HTML] XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
…, RP Nair, A Franke… - Nature …, 2012 - nature.com
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …