Genetic differences between Arabidopsis thaliana accessions underlie the plant’s extensive
phenotypic variation, and until now these have been interpreted largely in the context of the …

Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas
cancer types from 8,705 patients detects alternative splicing events and tumor variants by …

High-throughput RNA sequencing is an increasingly accessible method for studying gene
structure and activity on a genome-wide scale. A critical step in RNA-seq data analysis is the …

10.7554/eLife.05255.001 Epigenome modulation potentially provides a mechanism for
organisms to adapt, within and between generations. However, neither the extent to which this …

Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups 1 , this diversity encompasses a rich discovery potential …

Transcript alterations often result from somatic changes in cancer genomes 1 . Various forms
of RNA alterations have been described in cancer, including overexpression 2 , altered …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

The nonsense-mediated decay ( NMD ) surveillance pathway can recognize erroneous
transcripts and physiological mRNAs, such as precursor mRNA alternative splicing ( AS ) variants…

Motivation: Understanding the occurrence and regulation of alternative splicing (AS) is a key
task towards explaining the regulatory processes that shape the complex transcriptomes of …

Most human protein-coding genes are regulated by multiple, distinct promoters, suggesting
that the choice of promoter is as important as its level of transcriptional activity. However, …