Normative models are a class of emerging statistical techniques useful for understanding
the heterogeneous biology underlying psychiatric disorders at the level of the individual …

Standard univariate analysis of neuroimaging data has revealed a host of neuroanatomical
and functional differences between healthy individuals and patients suffering a wide range of …

Background Despite many successes, the case-control approach is problematic in biomedical
science. It introduces an artificial symmetry whereby all clinical groups (eg, patients and …

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …

Importance Schizophrenia and bipolar disorder are severe and complex brain disorders
characterized by substantial clinical and biological heterogeneity. However, case-control …

The brain’s remarkable capacity for language requires bidirectional interactions between
functionally specialized brain regions. We used magnetoencephalography to investigate …

Autistic spectrum disorder (ASD) is accompanied by subtle and spatially distributed differences
in brain anatomy that are difficult to detect using conventional mass-univariate methods (…

BACKGROUND: Methods of analysis that examine the pattern of cerebral activity over the
whole brain have been used to identify and predict neurocognitive states in healthy individuals…

Heterogeneity is a key feature of all psychiatric disorders that manifests on many levels,
including symptoms, disease course, and biological underpinnings. These form a substantial …

Autism spectrum disorder (ASD) is a neurodevelopmental condition with multiple causes,
comorbid conditions, and a wide range in the type and severity of symptoms expressed by …