Potentially pathogenic alterations have been identified in individuals with autism spectrum
disorders (ASDs) within a variety of key neurodevelopment genes. While this hints at a …

Background The need for scalable high-throughput screening (HTS) approaches for 3D human
stem cell platforms remains a central challenge for disease modeling and drug discovery…

Microglial activation in crossing white matter tracts is a hallmark of noncystic periventricular
leukomalacia (PVL), the leading pathology underlying cerebral palsy in prematurely born …

Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the
function of neural networks throughout the brain. Multiple lines of evidence suggest that a …

Perinatal brain injuries are a leading cause of cerebral palsy worldwide. The potential of stem
cell therapy to prevent or reduce these impairments has been widely discussed within the …

Carboxypeptidase E (CPE) is involved in maturation of neuropeptides and sorting of brain‐derived
neurotrophic factor (BDNF) to the regulated pathway for activity‐dependent secretion …

Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental condition.
Symptoms of ASD cover the spectrum from mild qualitative differences in social interaction to …

Objective Neonatal white matter injury (NWMI) is the leading cause of cerebral palsy and
other neurocognitive deficits in prematurely‐born children, and no restorative therapies exist. …

This is a protocol for derivation of glial restricted precursor (GRP) cells from the spinal cord
of E13 mouse fetuses. These cells are early precursors within the oligodendrocytic cell …

Periventricular leukomalacia, PVL, is the leading cause of cerebral palsy in prematurely born
infants, and therefore more effective interventions are required. The objective of this study …