Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
[HTML][HTML] An atlas of dynamic chromatin landscapes in mouse fetal development
The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource
for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental …
for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental …
[HTML][HTML] Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
…, D Hammaker, DL Boyle, A Wildberg… - Nature …, 2018 - nature.com
Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid
arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA …
arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA …
Normalization and noise reduction for single cell RNA-seq experiments
A major roadblock towards accurate interpretation of single cell RNA-seq data is large technical
noise resulted from small amount of input materials. The existing methods mainly aim to …
noise resulted from small amount of input materials. The existing methods mainly aim to …
[HTML][HTML] Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function
Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that
remains an unmet medical need despite improved therapy. This limitation likely reflects the …
remains an unmet medical need despite improved therapy. This limitation likely reflects the …
[HTML][HTML] Assessing characteristics of RNA amplification methods for single cell RNA sequencing
Background Recently, measurement of RNA at single cell resolution has yielded surprising
insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable …
insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable …
Computational schemes for the prediction and annotation of enhancers from epigenomic assays
Identifying and annotating distal regulatory enhancers is critical to understand the
mechanisms that control gene expression and cell-type-specific activities. Next-generation …
mechanisms that control gene expression and cell-type-specific activities. Next-generation …
Systematic mapping of chromatin state landscapes during mouse development
Embryogenesis requires epigenetic information that allows each cell to respond appropriately
to developmental cues. Histone modifications are core components of a cell’s epigenome, …
to developmental cues. Histone modifications are core components of a cell’s epigenome, …
Protein structure refinement with adaptively restrained homologous replicas
D Della Corte, A Wildberg… - … : Structure, Function, and …, 2016 - Wiley Online Library
A novel protein refinement protocol is presented which utilizes molecular dynamics (MD)
simulations of an ensemble of adaptively restrained homologous replicas. This approach adds …
simulations of an ensemble of adaptively restrained homologous replicas. This approach adds …
Author Correction: An atlas of dynamic chromatin landscapes in mouse fetal development
In this Article, there are several errors. In Figure 3i, minus signs were missing from the P values;
they should read P= 2.8× 10− 100 and P= 3.1× 10− 11. In Fig. 5e, the maximum value on …
they should read P= 2.8× 10− 100 and P= 3.1× 10− 11. In Fig. 5e, the maximum value on …