Patients with prostate cancer frequently show resistance to androgen-deprivation therapy, a
condition known as castration-resistant prostate cancer (CRPC). Acquiring a better …

Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a
tumor suppressor gene (TSG) 1 . It has been hypothesized that subtle variations in TSG …

Numerous studies have established a causal link between aberrant mammalian target of
rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have …

Background Cell entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
depends on binding of the viral spike (S) proteins to angiotensin-converting enzyme 2 and on …

The microbiota comprises the microorganisms that live in close contact with the host, with
mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence of …

The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or
deleted frequently in various human cancers. Subtle reductions in PTEN expression levels …

Tumor-associated macrophages (TAMs) represent a major component of the tumor
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a strategy to …

Prosenescence therapy has recently emerged as a novel therapeutic approach for treating
cancer. However, this concept is challenged by conflicting evidence showing that the …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN
mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a …