To understand how the skeletal muscle lineage is induced during vertebrate embryogenesis,
we have sought to identify the regulatory molecules that mediate induction of the myogenic …

During gastrulation in amniotes, epiblast cells ingress through the primitive streak and migrate
away to form endodermal, mesodermal, and extraembryonic structures. Here we analyze …

Background: The importance of endogenous antagonists in intracellular signal transduction
pathways is becoming increasingly recognized. There is evidence in cultured mammalian …

The neural tube, floor plate and notochord are axial tissues in the vertebrate embryo which
have been demonstrated to play a role in somite morphogenesis. Using in vitro co-culture of …

Talpid 3 is a classical chicken mutant with abnormal limb patterning and malformations in
other regions of the embryo known to depend on Hedgehog signaling. We combined the ease …

miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several
miRNAs, expressed exclusively in muscle, play important roles during muscle development, …

The formation of a complex multicellular organism from a single cell is one of the most amazing
processes of biology. Embryonic development is characterized by the careful regulation …

In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm,
we have isolated a novel chick Wnt gene, chick Wnt6. This gene encodes the first pan-…

The mammalian body plan is shaped by rhythmic segmentation of mesoderm into somites,
which are transient embryonic structures that form down each side of the neural tube. We …

In vertebrate embryos, cardiac progenitor cells (CPCs) undergo long-range migration after
emerging from the primitive streak during gastrulation. Together with other mesoderm …