Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated
exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant …

Empirical evidences suggest that both common and rare variants contribute to complex
disease etiology. Although the effects of common variants have been thoroughly assessed in …

Objective Sleep disturbances are associated with increased risk of migraine, however the
extent of shared underlying biology and the direction of causal relationships between these …

Both mild and severe epilepsies are influenced by variants in the same genes, yet an
explanation for the resulting phenotypic variation is unknown. As part of the ongoing Epi25 …

Objective To assess whether migraine may be genetically and/or causally associated with
inflammatory bowel disease (IBD) or celiac disease. Background Migraine has been linked to …

In the past few years, a plethora of methods for rare variant association with phenotype have
been proposed. These methods aggregate information from multiple rare variants across …

To discover novel genetic risk factors underlying amyotrophic lateral sclerosis (ALS), we
aggregated exomes from 3,864 cases and 7,839 ancestry matched controls. We observed a …

… Topp 5 , Andrea E. Byrnes 1 2 3 , Claire Churchhouse 1 2 3 , Hemali Phatnani 6 , Bradley N.
Smith 5 , Evadnie Rampersaud 7 , Gang Wu 7 , Joanne Wuu 8 , Aleksey Shatunov 9 , Alfredo …

First, we propose two methods for aggregation of rare variants in data from Genome-wide
Association Studies (GWAS), a weighted haplotype-based approach and an imputation-based …