MicroRNAs (miRNA) are a recently discovered class of noncoding RNAs that negatively
regulate gene expression. Recent evidence indicates that miRNAs may play an important role in …

Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer deaths among women in
the United States, but its pathogenesis is poorly understood 1 , 2 , 3 . Some epithelial …

Alterations in p53 and Rb pathways are observed frequently in epithelial ovarian cancer (EOC).However,
their roles in EOC initiation remain uncertain. Using a single intrabursal …

Ovarian cancer is the second most common gynecological neoplasm with over 20,000 new
cases and 15,000 deaths predicted in 2006 (1). Although significant decreases in mortality …

Purpose: The miR-34 family is directly transactivated by tumor suppressor p53, which is
frequently mutated in human epithelial ovarian cancer (EOC). We hypothesized that miR-34 …

BRCA1 is proposed to be a tumor suppressor gene. To explore the biological function of
BRCA1, a partial deletion (amino acids 300-361) of mouse Brca1 exon 11 was introduced into …

Pathways mediated by p53 and Rb are frequently altered in aggressive human cancers,
including prostate carcinoma. To test directly the roles of p53 and Rb in prostate carcinogenesis…

BRCA1 has been implicated in the transcriptional regulation of DNA damage–inducible
genes that function in cell cycle arrest. To explore the mechanistic basis for this regulation, a …

Recent observations suggest that p53 mutations are responsible not only for growth of
primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated …

Progress in biomedical imaging depends on the development of probes that combine low
toxicity with high sensitivity, resolution, and stability. Toward that end, a new class of highly …