User profiles for Andrea Lauria
Andrea LauriaUniversity of Turin, Italy Verified email at unito.it Cited by 128 |
Metabolic control of DNA methylation in naive pluripotent cells
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental
plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 …
plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 …
[HTML][HTML] DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells
The correct establishment of DNA methylation patterns during mouse early development is
essential for cell fate specification. However, the molecular targets as well as the …
essential for cell fate specification. However, the molecular targets as well as the …
[HTML][HTML] Tissue memory relies on stem cell priming in distal undamaged areas
…, M Watanabe, V Proserpio, G Piacenti, A Lauria… - Nature Cell …, 2023 - nature.com
Epithelial cells that participated in wound repair elicit a more efficient response to future
injuries, which is believed to be locally restricted. Here we show that cell adaptation resulting …
injuries, which is believed to be locally restricted. Here we show that cell adaptation resulting …
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia
Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that
dramatically increases mortality in various diseases, most notably in cancer patients with a …
dramatically increases mortality in various diseases, most notably in cancer patients with a …
Identification of altered biological processes in heterogeneous RNA-sequencing data by discretization of expression profiles
A Lauria, S Peirone, MD Giudice, F Priante… - Nucleic acids …, 2020 - academic.oup.com
Heterogeneity is a fundamental feature of complex phenotypes. So far, genomic screenings
have profiled thousands of samples providing insights into the transcriptome of the cell. …
have profiled thousands of samples providing insights into the transcriptome of the cell. …
The acetyltransferase p300 is recruited in trans to multiple enhancer sites by lncSmad7
M Maldotti, A Lauria, F Anselmi, I Molineris… - Nucleic Acids …, 2022 - academic.oup.com
The histone acetyltransferase p300 (also known as KAT3B) is a general transcriptional
coactivator that introduces the H3K27ac mark on enhancers triggering their activation and gene …
coactivator that introduces the H3K27ac mark on enhancers triggering their activation and gene …
Lifelong tissue memory relies on spatially organised dedicated progenitors located distally from the injury
It is believed epithelial cells that have participated in a wound repair elicit a more efficient but
locally restricted response to future injuries. However here we show that the cell adaptation …
locally restricted response to future injuries. However here we show that the cell adaptation …
Hair follicle stem cell progeny heal blisters while pausing skin development
Injury in adult tissue generally reactivates developmental programs to foster regeneration,
but it is not known whether this paradigm applies to growing tissue. Here, by employing …
but it is not known whether this paradigm applies to growing tissue. Here, by employing …
[HTML][HTML] Expression and Function of C1orf132 Long-Noncoding RNA in Breast Cancer Cell Lines and Tissues
miR-29b2 and miR-29c play a suppressive role in breast cancer progression. C1orf132 (also
named MIR29B2CHG) is the host gene for generating both microRNAs. However, the …
named MIR29B2CHG) is the host gene for generating both microRNAs. However, the …
[HTML][HTML] Genome-Wide analysis of Smad7-mediated transcription in mouse embryonic stem cells
Smad7 has been identified as a negative regulator of the transforming growth factor TGF-β
pathway by direct interaction with the TGF-β type I receptor (TβR-I). Although Smad7 has also …
pathway by direct interaction with the TGF-β type I receptor (TβR-I). Although Smad7 has also …