Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
…, JW Carnwath, A Lucas-Hahn… - Proceedings of the …, 2011 - National Acad Sciences
Zinc-finger nucleases (ZFNs) are powerful tools for producing gene knockouts (KOs) with
high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in laboratory …
high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in laboratory …
Telomere length is reset during early mammalian embryogenesis
S Schaetzlein, A Lucas-Hahn… - Proceedings of the …, 2004 - National Acad Sciences
The enzyme telomerase is active in germ cells and early embryonic development and is
crucial for the maintenance of telomere length. Whereas the different length of telomeres in …
crucial for the maintenance of telomere length. Whereas the different length of telomeres in …
[PDF][PDF] Parental genome unification is highly error-prone in mammalian embryos
…, G Lukinavičius, K Elder, M Blayney, A Lucas-Hahn… - Cell, 2021 - cell.com
Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …
Messenger RNA expression patterns in bovine embryos derived from in vitro procedures and their implications for development
C Wrenzycki, D Herrmann, A Lucas-Hahn… - Reproduction …, 2004 - CSIRO Publishing
The preimplantation bovine embryo is initially under the control of maternal genomic information
that is accumulated during oogenesis. The genetic programme of development soon …
that is accumulated during oogenesis. The genetic programme of development soon …
Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli
…, B Petersen, JW Carnwath, A Lucas‐Hahn… - …, 2009 - Wiley Online Library
Oropeza M, Petersen B, Carnwath JW, Lucas‐Hahn A, Lemme E, Hassel P, Herrmann D,
Barg‐Kues B, Holler S, Queisser A‐L, Schwinzer R, Hinkel R, Kupatt C, Niemann H. …
Barg‐Kues B, Holler S, Queisser A‐L, Schwinzer R, Hinkel R, Kupatt C, Niemann H. …
Pigs transgenic for human thrombomodulin have elevated production of activated protein C
…, W Ramackers, A Tiede, A Lucas‐Hahn… - …, 2009 - Wiley Online Library
Petersen B, Ramackers W, Tiede A, Lucas‐Hahn A, Herrmann D, Barg‐Kues B, Schuettler
W, Friedrich L, Schwinzer R, Winkler M, Niemann H. Pigs transgenic for human …
W, Friedrich L, Schwinzer R, Winkler M, Niemann H. Pigs transgenic for human …
Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes
B Petersen, A Frenzel, A Lucas‐Hahn… - …, 2016 - Wiley Online Library
Background Xenotransplantation is considered to be a promising solution to the growing
demand for suitable donor organs for transplantation. Despite tremendous progress in the …
demand for suitable donor organs for transplantation. Despite tremendous progress in the …
Transgenic expression of human heme oxygenase‐1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys
B Petersen, W Ramackers, A Lucas‐Hahn… - …, 2011 - Wiley Online Library
Petersen B, Ramackers W, Lucas‐Hahn A, Lemme E, Hassel P, Queißer A‐L, Herrmann D,
Barg‐Kues B, Carnwath JW, Klose J, Tiede A, Friedrich L, Baars W, Schwinzer R, Winkler M, …
Barg‐Kues B, Carnwath JW, Klose J, Tiede A, Friedrich L, Baars W, Schwinzer R, Winkler M, …
DNA methylation in porcine preimplantation embryos developed in vivo and produced by in vitro fertilization, parthenogenetic activation and somatic cell nuclear …
…, E Østrup, M Vejlsted, H Niemann, A Lucas-Hahn… - Epigenetics, 2011 - Taylor & Francis
DNA demethylation and remethylation are crucial for reprogramming of the differentiated
parental/somatic genome in the recipient ooplasm upon somatic cell nuclear transfer. Here, we …
parental/somatic genome in the recipient ooplasm upon somatic cell nuclear transfer. Here, we …
[HTML][HTML] Desorption electrospray ionization mass spectrometry reveals lipid metabolism of individual oocytes and embryos
…, P Oliveri, LS Eberlin, J Heinzmann, A Lucas-Hahn… - PloS one, 2013 - journals.plos.org
Alteration of maternal lipid metabolism early in development has been shown to trigger
obesity, insulin resistance, type 2 diabetes and cardiovascular diseases later in life in humans …
obesity, insulin resistance, type 2 diabetes and cardiovascular diseases later in life in humans …