Old yellow enzyme (OYE) is a NAD(P)H flavin oxidoreductase that in Trypanosoma cruzi (TcOYE)
catalyzes prostaglandin PGF2α synthesis and reduction of some trypanocidal drugs. …

Background The establishment of the nuclear membrane resulted in the physical separation
of transcription and translation, and presented early eukaryotes with a formidable challenge…

Gene regulation is mainly post-transcriptional in trypanosomatids. The stability of mRNA
and access to polysomes are thought to be tightly regulated, allowing Trypanosoma cruzi to …

Nucleo‐cytoplasmic RNA export is an essential post‐transcriptional step to control gene
expression in eukaryotic cells and is poorly understood in apicomplexan parasites. With the …

The co-synthesis of DNA and RNA potentially generates conflicts between replication and
transcription, which can lead to genomic instability. In trypanosomatids, eukaryotic parasites …

We characterized a gene encoding an YchF-related protein, TcYchF, potentially associated
with the protein translation machinery of Trypanosoma cruzi. YchF belongs to the translation …

Introduction Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore,
we aimed to identify key factors associated with altered lung function and CT scan …

… Bruno Dallagiovanna,* Claire Plazanet-Menut,† Sueli Fumie Yamada Ogatta,‡ Andrea R. …
2001 Academic Press R., Krieger, MA, and Goldenberg, S. 2001. Trypanosoma cruzi: A gene …

Background We report a genomic surveillance of SARS-CoV-2 lineages circulating in Paraná,
southern Brazil, from March 2020 to April 2021. Our analysis, based on 333 genomes, …

The scarcity of molecular tools for genetic manipulation is a critical obstacle for functional
genomics studies on Trypanosoma cruzi. The current study adapted an inducible site-specific …