Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the
functional effector or memory T cell states 1 , 2 , 3 , 4 , 5 – 6 . Here we identify the nuclear factor …

CD8 + T cells recognizing tumor-specific antigens are detected in cancer patients but are
dysfunctional. Here we developed a tamoxifen-inducible liver cancer mouse model with a …

‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to
chronic antigen stimulation, first in the setting of chronic viral infection but more recently in …

Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1 , 2 , 3 , 4 – 5 . Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been …

Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to
progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability (for …

CD8 + T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

CD8 T cell activation and differentiation are tightly controlled, and dependent on the context
in which naïve T cells encounter antigen, can either result in functional memory or T cell …

Targeting cancer cells, as well as the nonmalignant stromal cells cross-presenting the tumor
antigen (Ag), can lead to the complete destruction of well-established solid tumors by …

The tumor barrier comprised of nonantigenic stromal cells may contribute to the failure of
tumor rejection. The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-…

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells 1 . How autoimmune T cell populations arise and are …