[HTML][HTML] Structural basis of UV DNA-damage recognition by the DDB1–DDB2 complex
A Scrima, R Koníčková, BK Czyzewski, Y Kawasaki… - Cell, 2008 - cell.com
Ultraviolet (UV) light-induced pyrimidine photodimers are repaired by the nucleotide excision
repair pathway. Photolesions have biophysical parameters closely resembling undamaged …
repair pathway. Photolesions have biophysical parameters closely resembling undamaged …
[HTML][HTML] The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
ES Fischer, A Scrima, K Böhm, S Matsumoto… - Cell, 2011 - cell.com
The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular
pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-…
pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-…
The regulation of mDia1 by autoinhibition and its release by Rho• GTP
M Lammers, R Rose, A Scrima, A Wittinghofer - The EMBO journal, 2005 - embopress.org
Formins induce the nucleation and polymerisation of unbranched actin filaments via the
formin‐homology domains 1 and 2. Diaphanous‐related formins (Drfs) are regulated by a …
formin‐homology domains 1 and 2. Diaphanous‐related formins (Drfs) are regulated by a …
[HTML][HTML] Structural insights into HypB, a GTP-binding protein that regulates metal binding
R Gasper, A Scrima, A Wittinghofer - Journal of biological chemistry, 2006 - ASBMB
HypB is a prokaryotic metal-binding guanine nucleotide-binding protein that is essential for
nickel incorporation into hydrogenases. Here we solved the x-ray structure of HypB from …
nickel incorporation into hydrogenases. Here we solved the x-ray structure of HypB from …
The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues
A Scrima, C Thomas, D Deaconescu… - The EMBO …, 2008 - embopress.org
The GTP‐binding protein Rap1 regulates integrin‐mediated and other cell adhesion processes.
Unlike most other Ras‐related proteins, it contains a threonine in switch II instead of a …
Unlike most other Ras‐related proteins, it contains a threonine in switch II instead of a …
Dimerisation‐dependent GTPase reaction of MnmE: how potassium acts as GTPase‐activating element
A Scrima, A Wittinghofer - The EMBO journal, 2006 - embopress.org
MnmE, a Guanine nucleotide‐binding protein conserved between bacteria and man, is
involved in the modification of tRNAs. Here we provide biochemical and X‐ray structural …
involved in the modification of tRNAs. Here we provide biochemical and X‐ray structural …
[HTML][HTML] Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions
Yeast telomeres comprise irregular TG 1-3 DNA repeats bound by the general transcription
factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a protective cap that inhibits …
factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a protective cap that inhibits …
[PDF][PDF] Structural evidence for a common intermediate in small G protein-GEF reactions
C Thomas, I Fricke, A Scrima, A Berken, A Wittinghofer - Molecular cell, 2007 - cell.com
Rho of plants (Rop) proteins belong to the superfamily of small GTP-binding (G) proteins
and are vital regulators of signal transduction in plants. In order to become activated, Rop …
and are vital regulators of signal transduction in plants. In order to become activated, Rop …
[HTML][HTML] Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
A Scrima, ES Fischer, GM Lingaraju, K Böhm… - FEBS letters, 2011 - Elsevier
The DDB1–DDB2–CUL4–RBX1 complex serves as the primary detection device for UV-induced
lesions in the genome. It simultaneously functions as a CUL4 type E3 ubiquitin ligase. …
lesions in the genome. It simultaneously functions as a CUL4 type E3 ubiquitin ligase. …
Arranged sevenfold: structural insights into the C-terminal oligomerization domain of human C4b-binding protein
…, M Dal Peraro, M Daneschdar, A Scrima… - Journal of molecular …, 2013 - Elsevier
The complement system as a major part of innate immunity is the first line of defense
against invading microorganisms. Orchestrated by more than 60 proteins, its major task is to …
against invading microorganisms. Orchestrated by more than 60 proteins, its major task is to …