Faecal incontinence, which is defined by the unintentional loss of solid or liquid stool, has a
worldwide prevalence of ≤7% in community-dwelling adults and can markedly impair …

Background & Aims Weight loss after pharmacotherapy varies greatly. We aimed to examine
associations of quantitative gastrointestinal and psychological traits with obesity, and to …

The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but
our ability to study gut microbial ecosystems in their entirety was limited by culture-based …

Background & Aims There is an unclear relationship among bowel symptoms, excretion of
unconjugated fecal bile acid (UBA), and colonic transit in irritable bowel syndrome (IBS). We …

Background Gastric emptying (GE) is measured in pharmacodynamic and diagnostic studies.
Our aim was to assess inter‐ and intra‐subject coefficients of variation (COV) of …

The purpose of this expert review is to synthesize the existing evidence on the management
of Clostridium difficile infection in patients with underlying inflammatory bowel disease. The …

Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC)
based on comparisons to placebo using Bayesian network meta-analysis. Data sources …

Description: The purpose of this clinical practice update review is to describe key principles
in the diagnosis and management of functional gastrointestinal (GI) symptoms in patients …

Altered concentrations of bile acid (BA) in the colon can cause diarrhea or constipation.
More than 25% of patients with irritable bowel syndrome with diarrhea or chronic diarrhea in …

OBJECTIVE To investigate the pharmacokinetics (PK), pharmacodynamics, and safety of
single-dose RM-131 in type 2 diabetic patients with gastrointestinal cardinal symptoms (GCSI) …