Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration …
An accurate means of predicting blood–brain barrier (BBB) penetration and blood–brain
partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical …
partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical …
[HTML][HTML] Restraint stress-induced morphological changes at the blood-brain barrier in adult rats
Stress is well-known to contribute to the development of both neurological and psychiatric
diseases. While the role of the blood-brain barrier is increasingly recognized in the …
diseases. While the role of the blood-brain barrier is increasingly recognized in the …
[HTML][HTML] Comparison of a rat primary cell-based blood-brain barrier model with epithelial and brain endothelial cell lines: gene expression and drug transport
Cell culture-based blood-brain barrier (BBB) models are useful tools for screening of CNS
drug candidates. Cell sources for BBB models include primary brain endothelial cells or …
drug candidates. Cell sources for BBB models include primary brain endothelial cells or …
[HTML][HTML] Induction of NLRP3 inflammasome activation by heme in human endothelial cells
Hemolytic or hemorrhagic episodes are often associated with inflammation even when
infectious agents are absent suggesting that red blood cells (RBCs) release damage-associated …
infectious agents are absent suggesting that red blood cells (RBCs) release damage-associated …
[HTML][HTML] Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells
Background Sepsis and jaundice are common conditions in newborns that can lead to brain
damage. Though lipopolysaccharide (LPS) is known to alter the integrity of the blood-brain …
damage. Though lipopolysaccharide (LPS) is known to alter the integrity of the blood-brain …
Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue
…, H Wolburg, P Sipos, S Veszelka, A Tóth… - European journal of …, 2009 - Elsevier
Intranasal administration of molecules has been investigated as a non-invasive way for
delivery of drugs to the brain in the last decade. Circumvention of both the blood–brain barrier …
delivery of drugs to the brain in the last decade. Circumvention of both the blood–brain barrier …
Hypoxia triggers osteochondrogenic differentiation of vascular smooth muscle cells in an HIF-1 (hypoxia-inducible factor 1)–dependent and reactive oxygen species …
Objective— Vascular calcification is associated with high risk of cardiovascular events and
mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
[HTML][HTML] Body position influences which neural structures are recruited by lumbar transcutaneous spinal cord stimulation
Transcutaneous stimulation of the human lumbosacral spinal cord is used to evoke spinal
reflexes and to neuromodulate altered sensorimotor function following spinal cord injury. Both …
reflexes and to neuromodulate altered sensorimotor function following spinal cord injury. Both …
[HTML][HTML] Regulation of vascular calcification by reactive oxygen species
Vascular calcification is the deposition of hydroxyapatite crystals in the medial or intimal
layers of arteries that is usually associated with other pathological conditions including but not …
layers of arteries that is usually associated with other pathological conditions including but not …
Patented in vitro blood-brain barrier models in CNS drug discovery
A Tóth, S Veszelka, S Nakagawa… - Recent Patents on …, 2011 - ingentaconnect.com
The blood-brain barrier (BBB) is a regulatory interface between the circulation and the
central nervous system (CNS). Therapy of neurological diseases is limited due to restricted …
central nervous system (CNS). Therapy of neurological diseases is limited due to restricted …