It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis,
thereby causing binucleation and limiting regenerative repair after injury. This suggests that …

Both obesity and sarcopenia are frequently associated in ageing, and together may promote
the progression of related conditions such as diabetes and frailty. However, little is known …

Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise
nutritional components driving this response remain elusive. Here, by mimicking amino acid (…

Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and
remains the single most important clinical predictor of cardiac mortality. The molecular …

Animal models of pressure overload are valuable for understanding hypertensive heart disease.
We characterised a surgical model of pressure overload-induced hypertrophy in C57BL/…

We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted
overexpression of the dominant negative W v mutant protein (dn-c-kit-Tg) respond to pressure …

The ‘fight or flight’ response to physiological stress involves sympathetic nervous system
activation, catecholamine release and adrenergic receptor stimulation. In the heart, this induces …

Primary cardiomyocytes are invaluable for understanding postnatal heart development.
However, a universal method to obtain freshly purified cardiomyocytes without using different age…

Background Over 100 mammalian G protein-coupled receptors are yet to be matched with
endogenous ligands; these so-called orphans are prospective drug targets for the treatment of …

Nutrition and resilience are linked, though it is not yet clear how diet confers stress resistance
or the breadth of stressors that it can protect against. We have previously shown that …