Growing evidence shows that epigenetic mechanisms contribute to complex traits, with
implications across many fields of biology. In plant ecology, recent studies have attempted to …

Transposon-based gene vectors have become indispensable tools in vertebrate genetics
for applications ranging from insertional mutagenesis and transgenesis in model species to …

Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity
crisis, leading to widespread epidemics and population loss. Owing to genetic variation in …

As the human life span increases, the number of people suffering from cognitive decline is
rising dramatically. The mechanisms underlying age-associated memory impairment are, …

The inherent risks associated with vector insertion in gene therapy need to be carefully
assessed. We analyzed the genome-wide distributions of Sleeping Beauty (SB) and piggyBac (…

Background Organisms typically face infection by diverse pathogens, and hosts are thought
to have developed specific responses to each type of pathogen they encounter. The advent …

Helitron transposons capture and mobilize gene fragments in eukaryotes, but experimental
evidence for their transposition is lacking in the absence of an isolated active element. Here …

Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration
in human chromosome 19q13.42. The AAV non-structural protein Rep appears to target a …

RBM10 encodes an RNA binding protein. Mutations in RBM10 are known to cause multiple
congenital anomaly syndrome in male humans, the TARP syndrome. However, the …

Background Global increase in ambient temperatures constitute a significant challenge to
wild and cultivated plant species. Forward genetic analyses of individual temperature-…