IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that …
M Chmielewski, C Kopecky, AA Hombach, H Abken - Cancer research, 2011 - AACR
During malignant progression cancer cells tend to lose cell surface expression of MHC and
other immune antigens, making them invisible to cytotoxic T cells and therefore inaccessible …
other immune antigens, making them invisible to cytotoxic T cells and therefore inaccessible …
Of CAR s and TRUCK s: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
M Chmielewski, AA Hombach… - Immunological reviews, 2014 - Wiley Online Library
Adoptive T‐cell therapy recently achieved impressive efficacy in early phase trials, in particular
in hematologic malignancies, strongly supporting the notion that the immune system can …
in hematologic malignancies, strongly supporting the notion that the immune system can …
Tumor-specific T cell activation by recombinant immunoreceptors: CD3ζ signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and …
A Hombach, A Wieczarkowiecz… - The Journal of …, 2001 - journals.aai.org
Recombinant immunoreceptors with specificity for the carcinoembryonic Ag (CEA) can
redirect grafted T cells to a MHC/Ag-independent antitumor response. To analyze receptor-…
redirect grafted T cells to a MHC/Ag-independent antitumor response. To analyze receptor-…
T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against …
M Chmielewski, A Hombach, C Heuser… - The Journal of …, 2004 - journals.aai.org
Chimeric TCRs with an Ab-derived binding domain confer predefined specificity and MHC-independent
target binding to T cells for use in adoptive immunotherapy. We investigated the …
target binding to T cells for use in adoptive immunotherapy. We investigated the …
Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
…, A Di Stasi, H Abken, A Hombach… - Blood, The Journal …, 2007 - ashpublications.org
Adoptive transfer of Epstein Barr virus (EBV)–specific cytotoxic T-lymphocytes (EBV-CTLs)
has shown that these cells persist in patients with EBV + Hodgkin lymphoma (HD) to produce …
has shown that these cells persist in patients with EBV + Hodgkin lymphoma (HD) to produce …
OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+ T cells
AA Hombach, J Heiders, M Foppe… - …, 2012 - Taylor & Francis
Adoptive therapy with chimeric antigen receptor (CAR) redirected T cells recently showed
remarkable anti-tumor efficacy in early phase clinical trials; self-repression of the immune …
remarkable anti-tumor efficacy in early phase clinical trials; self-repression of the immune …
Chronic inflammatory bowel disease and cancer.
C Pohl, A Hombach, W Kruis - Hepato-gastroenterology, 2000 - europepmc.org
Colorectal cancer represents the major cause for excess morbidity and mortality by malignant
disease in ulcerative colitis as well as in Crohn's disease. The risk for ulcerative colitis …
disease in ulcerative colitis as well as in Crohn's disease. The risk for ulcerative colitis …
[HTML][HTML] Antigen-specific T-cell activation independently of the MHC: chimeric antigen receptor-redirected T cells
M Chmielewski, AA Hombach, H Abken - Frontiers in immunology, 2013 - frontiersin.org
Adoptive T-cell therapy has recently shown promise in initiating a lasting anti-tumor response
with spectacular therapeutic success in some cases. Specific T-cell therapy, however, is …
with spectacular therapeutic success in some cases. Specific T-cell therapy, however, is …
Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28‐OX40 signalling
AA Hombach, H Abken - International journal of cancer, 2011 - Wiley Online Library
The therapeutic success of adoptive therapy with chimeric antigen receptor (CAR) engineered
T cells depends on the appropriate costimulation of CD3ζ to induce full T cell activation. …
T cells depends on the appropriate costimulation of CD3ζ to induce full T cell activation. …
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice
…, G Rappl, M Nowak, IH Schmidt–Wolf, AA Hombach… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: New treatment approaches are needed for patients with pancreatic
adenocarcinoma. Carcinoembryonic antigen (CEA) is highly expressed on the surface of …
adenocarcinoma. Carcinoembryonic antigen (CEA) is highly expressed on the surface of …