Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice
…, AM Piccinini, SR Paludan, MA Kowalska, AJ Kungl… - Nature medicine, 2009 - nature.com
Atherosclerosis is characterized by chronic inflammation of the arterial wall due to
chemokine-driven mononuclear cell recruitment 1 , 2 , 3 , 4 . Activated platelets can synergize with …
chemokine-driven mononuclear cell recruitment 1 , 2 , 3 , 4 . Activated platelets can synergize with …
[HTML][HTML] Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo
…, JP Gaudry, E Geretti, F Borlat, AJ Kungl… - Journal of Biological …, 2004 - ASBMB
In a recent study, we demonstrated that glycosaminoglycan (GAG) binding and oligomerization
are essential for the in vivo function of the chemokines MCP-1/CCL2, RANTES/CCL5, …
are essential for the in vivo function of the chemokines MCP-1/CCL2, RANTES/CCL5, …
Modulation of IgE reactivity of allergens by site‐directed mutagenesis: potential use of hypoallergenic variants for immunotherapy
…, B Kramer, G Casari, P Briza, AJ Kungl… - The FASEB …, 1998 - Wiley Online Library
Specific immunotherapy is an efficient treatment for patients suffering from type I allergy. The
mechanisms underlying successful immunotherapy are assumed to operate at the level of T …
mechanisms underlying successful immunotherapy are assumed to operate at the level of T …
[HTML][HTML] Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm
A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus,
the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic, …
the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic, …
[HTML][HTML] The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein α-synuclein
SF Falsone, AJ Kungl, A Rek, R Cappai… - Journal of biological …, 2009 - ASBMB
α-Synuclein is an intrinsically unstructured protein that binds to membranes, forms fibrils, and
is involved in neurodegeneration. We used a reconstituted in vitro system to show that the …
is involved in neurodegeneration. We used a reconstituted in vitro system to show that the …
A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in mice
…, A Curaj, A Popescu, A Zernecke, AJ Kungl… - Journal of the American …, 2010 - jacc.org
Objectives : A nonagonist monocyte chemotactic protein-1 (MCP-1/CCL2) mutant (PA508)
with increased affinity for glycosaminoglycans and thus competing with CCL2 was evaluated …
with increased affinity for glycosaminoglycans and thus competing with CCL2 was evaluated …
Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites
…, A Rek, R Mösl, D Pye, J Gallagher, AJ Kungl - Biochemistry, 2002 - ACS Publications
The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of
endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site. …
endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site. …
[HTML][HTML] Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains
…, K Richter, G Obermeyer, P Briza, AJ Kungl… - Journal of Biological …, 1997 - ASBMB
We have isolated a cDNA clone coding for a birch pollen allergen, Bet v 4. The deduced
amino acid sequence of Bet v 4 contained two typical EF-hand calcium-binding domains. …
amino acid sequence of Bet v 4 contained two typical EF-hand calcium-binding domains. …
[PDF][PDF] SERF protein is a direct modifier of amyloid fiber assembly
…, GE Wagner, DA Merle, EA Nollen, AJ Kungl… - Cell reports, 2012 - cell.com
The inherent cytotoxicity of aberrantly folded protein aggregates contributes substantially to
the pathogenesis of amyloid diseases. It was recently shown that a class of evolutionary …
the pathogenesis of amyloid diseases. It was recently shown that a class of evolutionary …
Interleukin-8 binds to syndecan-2 on human endothelial cells
…, W Atzenhofer, L Szilak, A Wabnig, AJ Kungl - Biochemical …, 2004 - portlandpress.com
Application of reverse transcription–PCR to total RNA prepared from TNF-α (tumour necrosis
factor-α)-stimulated HUVECs (human umbilical vein endothelial cells) revealed that the …
factor-α)-stimulated HUVECs (human umbilical vein endothelial cells) revealed that the …