The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …

Alzheimer’s disease (AD) is a severe 1 age-related neurodegenerative disorder characterized
by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal …

Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been extensively …

INTRODUCTION Vocal learning, the ability to imitate sounds, is a trait that has undergone
convergent evolution in several lineages of birds and mammals, including song-learning birds …

Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer’s disease. We
conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (…

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization …

The zebra finch is an important model organism in several fields 1 , 2 with unique relevance
to human neuroscience 3 , 4 . Like other songbirds, the zebra finch communicates through …

Severe and persistent disruptions to sleep and circadian rhythms are common in people with
opioid use disorder (OUD). Preclinical evidence suggests altered molecular rhythms in the …

Neuronal activity causes the rapid expression of immediate early genes that are crucial for
experience-driven changes to synapses, learning, and memory. Here, using both molecular …

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 …