PERIOD (PER) proteins are central components within the mammalian circadian oscillator,
and are believed to form a negative feedback complex that inhibits their own transcription at …

A diverse collection of trust-modeling algorithms for multi-agent systems has been developed
in recent years, resulting in significant breadth-wise growth without unified direction or …

Post-translational processes are essential for the generation and dynamics of mammalian
circadian rhythms. In particular, phosphorylation of the key circadian protein PER2 precisely …

The bacterium Photorhabdus luminescens is mutualistically associated with entomopathogenetic
nematodes. These nematodes invade insect larvae and release the bacteria from their …

While gene expression is a fundamental and tightly controlled cellular process that is regulated
at multiple steps, the exact contribution of each step remains unknown in any organism. …

Background The human leucocyte antigen (HLA) complex controls adaptive immunity by
presenting defined fractions of the intracellular and extracellular protein content to immune cells…

The success of cancer immunotherapy relies on the ability of cytotoxic T cells to specifically
recognize and eliminate tumor cells based on peptides presented by HLA-I. Although the …

Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in translation initiation.
They are induced by various stress conditions, including exposure to the environmental …

The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a
priority cancer target. Although the catalytic activity of AURORA-A is essential for its mitotic …

The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes
and enhances RNA polymerase II (Pol II) function, but its precise mode of action is poorly …