Epstein–Barr virus-induced gene 2 (EBI2, also known as GPR183) is a G-protein-coupled
receptor that is required for humoral immune responses; polymorphisms in the receptor have …

By using a combination of genetic, pharmacological, and anatomical approaches, we show
that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy …

To assess the contribution of potential central nervous system pathways implicated in the
control of appetite regulation and energy metabolism, it is essential to first identify appropriate …

Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated
from chum salmon pituitaries. Besides its effects on the aggregation of melanophores in fish …

7α,25-dihydroxycholesterol (7α,25-OHC) is a ligand for the G protein-coupled receptor EBI2;
however, the cellular sources of this oxysterol are undefined. 7α,25-OHC is synthesized …

To determine the importance of the NMDA receptor (NMDAR) in pain hypersensitivity after
injury, the NMDAR1 (NR1) subunit was selectively deleted in the lumbar spinal cord of adult …

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …

Multimeric assemblies of kainate (KA) receptor subunits form glutamate-gated ion channels
that mediate EPSCs and function as presynaptic modulators of neurotransmitter release at …

AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for
constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show …

Ciliopathies are a large group of clinically and genetically heterogeneous disorders caused
by defects in primary cilia. Here we identified mutations in TRAF3IP1 (TNF Receptor-…