Background Coronavirus induced disease 2019 (COVID-19) can be complicated by severe
organ damage leading to dysfunction of the lungs and other organs. The processes that …

Different mechanisms were proposed for opioid-induced analgesia and antihyperalgesia,
which might result in different pharmacodynamics. To address this issue, the time course of …

Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …

Background Severe COVID-19 induced acute respiratory distress syndrome (ARDS) often
requires extracorporeal membrane oxygenation (ECMO). Recent German health insurance …

Topical application of lidocaine is an effective approach for treatment of post-herpetic neuralgia
and other painful neuropathies. Lidocaine inhibits voltage-gated Na + channels and it …

Crohn’s disease (CD) is a painful inflammatory bowel disease with complex multigenic
inheritance. Suggested on the basis of a few isolated reports CD patients require significantly …

Objective Evaluate the accuracy and trending ability of the fourth-generation FloTrac/EV1000
(Edwards Lifesciences, Irvine, CA) system in patients with severe aortic valve stenosis by …

BACKGROUND The challenge of managing acute postoperative pain is the well tolerated
and effective administration of analgesics with a minimum of side effects. The standard …

For the quantification of propofol total and unbound drug concentrations a sensitive and
specific liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was …

BACKGROUND Remifentanil is an effective drug in peri-operative pain therapy, but it can
also induce and aggravate hyperalgesia. Supplemental administration of N 2 O may help to …