Leukaemias and other cancers possess a rare population of cells capable of the limitless
self-renewal necessary for cancer initiation and maintenance 1 , 2 , 3 , 4 , 5 , 6 , 7 . Eradication …

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA-…

The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development
of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We …

Leukemia stem cells (LSCs) are capable of limitless self-renewal and are responsible for
the maintenance of leukemia. Because selective eradication of LSCs could offer substantial …

We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene
induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Gene …

Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL)
possess unique biologic characteristics and often have an unfavorable prognosis. Gene …

Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded
with the Mediator complex, transcription factors and chromatin regulators, drive high …

The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex
that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 …

TP53, which encodes the tumor suppressor p53, is the most frequently mutated gene in human
cancer. The selective pressures shaping its mutational spectrum, dominated by missense …

Inhibition of the Menin (MEN1) and MLL (MLL1, KMT2A) interaction is a potential therapeutic
strategy for MLL-rearranged (MLL-r) leukemia. Structure-based design yielded the potent, …