Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic
development. Here we report that deletion of the DNA damage response factor 53BP1 …

In the adult brain, continual neurogenesis of olfactory neurons is sustained by the existence
of neural stem cells (NSCs) in the subependymal niche. Elimination of the cyclin-dependent …

Oncogene-induced replicative stress activates an Atr- and Chk1-dependent response, which
has been proposed to be widespread in tumors. We explored whether the presence of …

Replication comes with a price. The molecular gymnastics that occur on DNA during its
duplication frequently derive to a wide spectrum of abnormalities which are still far from …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

Replicative stress during embryonic development influences ageing and predisposition to
disease in adults. A protective mechanism against replicative stress is provided by the …

Replicative stress (RS) is a type of endogenous DNA damage that cells suffer every time they
duplicate their genomes, and which is further boosted by oncogenes. In mammals, the RS …

Post-translational modification of proteins by ubiquitin (Ub) and Ub-like modifiers regulates
DNA replication. We have previously shown that chromatin around replisomes is rich in …

DNA replication is facilitated by multiple factors that concentrate in the vicinity of replication
forks. Here, we developed an approach that combines the isolation of proteins on nascent …

Granulomas are immune cell aggregates formed in response to persistent inflammatory
stimuli. Granuloma macrophage subsets are diverse and carry varying copy numbers of their …