Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models
A Obregón-Henao, KA Arnett… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Over the last 10 years, Mycobacterium abscessus group strains have emerged as important
human pathogens, which are associated with significantly higher fatality rates than any other …
human pathogens, which are associated with significantly higher fatality rates than any other …
[HTML][HTML] Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
A Obregón-Henao, M Henao-Tamayo, IM Orme… - PloS one, 2013 - journals.plos.org
Background Tuberculosis is one of the world’s leading killers, stealing 1.4 million lives and
causing 8.7 million new and relapsed infections in 2011. The only vaccine against …
causing 8.7 million new and relapsed infections in 2011. The only vaccine against …
Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
…, C Klapholz, S Coulter, A Obregón‐Henao… - EMBO molecular …, 2015 - embopress.org
Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse
by the spread of multidrug resistance. We therefore examined whether stimulating …
by the spread of multidrug resistance. We therefore examined whether stimulating …
[HTML][HTML] Antigen presentation of mRNA-based and virus-vectored SARS-CoV-2 vaccines
GT Rijkers, N Weterings, A Obregon-Henao… - Vaccines, 2021 - mdpi.com
Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes
Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A number of …
Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A number of …
Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3
W Li, A Obregón-Henao, JB Wallach… - Antimicrobial agents …, 2016 - Am Soc Microbiol
In recent years, whole-cell-based screens for novel small molecule inhibitors active against
Mycobacterium tuberculosis in culture followed by the whole-genome sequencing of …
Mycobacterium tuberculosis in culture followed by the whole-genome sequencing of …
[HTML][HTML] Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity
…, V Singh, A Lau, RW Stokes, A Obregón-Henao… - PLoS …, 2013 - journals.plos.org
Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host
macrophage and identifying mycobacterial factors responsible for it are keys to better understand …
macrophage and identifying mycobacterial factors responsible for it are keys to better understand …
Lipoarabinomannan of Mycobacterium: Mannose capping by a multifunctional terminal mannosyltransferase
D Kaur, A Obregón-Henao, H Pham… - Proceedings of the …, 2008 - National Acad Sciences
Biosynthesis of phosphatidylinositol (PI)-containing lipoarabinomannan (LAM) and lipomannan
(LM) of Mycobacterium spp. follows a conserved pathway involving multiple membrane-…
(LM) of Mycobacterium spp. follows a conserved pathway involving multiple membrane-…
Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig
…, S Shang, A Obregon-Henao… - Clinical and vaccine …, 2012 - Am Soc Microbiol
The Beijing family of Mycobacterium tuberculosis strains is part of lineage 2 (also known as
the East Asian lineage). In clinical studies, we have observed that isolates from the …
the East Asian lineage). In clinical studies, we have observed that isolates from the …
[HTML][HTML] Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity
BK Podell, DF Ackart, A Obregon-Henao, SP Eck… - The American Journal of …, 2014 - Elsevier
Impaired glucose tolerance and type 2 diabetes were induced in guinea pigs to model the
emerging comorbidity of Mycobacterium tuberculosis infection in diabetic patients. Type 2 …
emerging comorbidity of Mycobacterium tuberculosis infection in diabetic patients. Type 2 …
Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T …
…, M Henao-Tamayo, A Obregon-Henao… - Clinical and vaccine …, 2011 - Am Soc Microbiol
Despite issues relating to variable efficacy in the past, the Mycobacterium bovis BCG vaccine
remains the basis for new-generation recombinant vaccines currently in clinical trials. To …
remains the basis for new-generation recombinant vaccines currently in clinical trials. To …