[HTML][HTML] Aβ (1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been
proposed to explain neurotoxicity in Alzheimerʼs disease (AD). Here, we present the three-…
proposed to explain neurotoxicity in Alzheimerʼs disease (AD). Here, we present the three-…
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal
Decades of previous efforts to develop renal-sparing polyene antifungals were misguided
by the classic membrane permeabilization model 1 . Recently, the clinically vital but also …
by the classic membrane permeabilization model 1 . Recently, the clinically vital but also …
Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
An Activity‐Based Sensing Approach for the Detection of Cyclooxygenase‐2 in Live Cells
Cyclooxygenase‐2 (COX‐2) overexpression is prominent in inflammatory diseases,
neurodegenerative disorders, and cancer. Directly monitoring COX‐2 activity within its native …
neurodegenerative disorders, and cancer. Directly monitoring COX‐2 activity within its native …
Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary
DD Meling, M Kathy, AS Arango, A Gonsioroski… - Reproductive …, 2022 - Elsevier
Widespread use of phthalates as solvents and plasticizers leads to everyday human exposure.
The mechanisms by which phthalate metabolites act as ovarian toxicants are not fully …
The mechanisms by which phthalate metabolites act as ovarian toxicants are not fully …
[HTML][HTML] Damage assessment of RC columns under the combined effects of contact explosion and axial loads by experimental and numerical investigations
Understanding physical phenomena such as blast shock waves produced by controlled
explosions is useful for problem solving in military and civil fields. The current study analyses the …
explosions is useful for problem solving in military and civil fields. The current study analyses the …
Endocannabinoid virodhamine is an endogenous inhibitor of human cardiovascular CYP2J2 epoxygenase
The human body contains endogenous cannabinoids (endocannabinoids) that elicit effects
similar to those of Δ 9 -tetrahydrocanabinol, the principal bioactive component of cannabis. …
similar to those of Δ 9 -tetrahydrocanabinol, the principal bioactive component of cannabis. …
[HTML][HTML] Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming
Eukaryotic cell homeostasis requires transfer of cellular components among organelles and
relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are …
relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are …
An allosteric binding site on sortilin regulates the trafficking of VLDL, PCSK9, and LDLR in hepatocytes
ApoB lipoproteins (apo B-Lp) are produced in hepatocytes, and their secretion requires the
cargo receptor sortilin. We examined the secretion of apo B-Lp-containing very low-density …
cargo receptor sortilin. We examined the secretion of apo B-Lp-containing very low-density …
Flexural and shear strengthening of RC beams reinforced with externally bonded CFRP laminates postfire exposure by experimental and analytical investigations
N Mejía, A Sarango, A Espinosa - Engineering Structures, 2024 - Elsevier
… (2) σ s = E s ɛ s 0 ≤ ɛ s < ɛ s y f s y ɛ s y ≤ ɛ s < ɛ s u … (6) F c c = ∫ 0 y n b σ c y ′ d
y ′ (7) ∫ 0 y n b σ c y ′ d y ′ + f s c ′ A s c − f s y A s t − σ f A f = 0 where f s c ′ is the …
y ′ (7) ∫ 0 y n b σ c y ′ d y ′ + f s c ′ A s c − f s y A s t − σ f A f = 0 where f s c ′ is the …