The photoisomerization of azobenzene has been known for almost 75 years but only recently
has this process been widely applied to biological systems. The central challenge of how …

Most azobenzene-based photoswitches use UV light for photoisomerization. This can limit
their application in biological systems, where UV light can trigger unwanted responses, …

Conspectus Recently, there has been a great deal of interest in using the photoisomerization
of azobenzene compounds to control specific biological targets in vivo. These azo …

The photoisomerization of azobenzenes provides a general means for the photocontrol of
molecular structure and function. For applications in vivo, however, the wavelength of …

Longer switching wavelengths and good photochemical yields and stabilities of the cis
isomers in reducing aqueous environments are achieved by introducing 2,2′‐aminoalkyl …

The photoisomerization of azobenzene has been used to control a wide variety of molecular
processes.[1] It has been applied to the photocontrol of biomolecular targets (peptides, …

β-Lapachone is an ortho-naphthoquinone natural product with significant antiproliferative
activity but suffers from adverse systemic toxicity. The use of photoremovable protecting …

The activity of DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1), which excises
oxidized base 8-oxoguanine (8-OG) from DNA, is closely linked to mutagenesis, genotoxicity, …

It is well established that aberrant cellular biochemical activity is strongly linked to the
formation and progression of various cancers. Assays that could aid in cancer diagnostics, …

Human carboxylesterase 2 (hCES2) converts anticancer prodrugs, such as irinotecan, into
their active metabolites via phase I drug metabolism. Owing to interindividual variability, …