[HTML][HTML] Sequencing by avidity enables high accuracy with low reagent consumption

…, AH Mah, H Wang, J Zhao, C Zhou, A Altomare… - Nature …, 2024 - nature.com
We present avidity sequencing, a sequencing chemistry that separately optimizes the
processes of stepping along a DNA template and that of identifying each nucleotide within the …

[HTML][HTML] Viral activation and ecological restructuring characterize a microbiome axis of spaceflight-associated immune activation

…, J Zhao, B Lajoie, RT Scott, A Altomare… - Research …, 2023 - ncbi.nlm.nih.gov
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes, which play a role in some space-derived health disorders. …

Characterizing and addressing error modes to improve sequencing accuracy

S Kruglyak, A Altomare, M Ambroso, V Dien, BR Lajoie… - bioRxiv, 2024 - biorxiv.org
The accuracy of a sequencing platform has traditionally been measured by the %Q30, or
percentage of data exceeding a basecall accuracy of 99.9%. Improvements to accuracy beyond …

Genome and Clonal Hematopoiesis Stability Contrasts with Immune, cfDNA, mitochondrial, and telomere length changes to Short Duration Spaceflight

…, J Moreno, A Boddicker, J Zhao, B Lajoie, A Altomare… - 2023 - researchsquare.com
The I4 mission, the first all-civilian orbital flight mission, investigated the physiological effects
of short duration spaceflight through a multi-omic approach. We analyzed telomere length, …

Coherent quantum annealing in a programmable 2,000 qubit Ising chain

…, S Suzuki, J Raymond, A Zucca, T Lanting, F Altomare… - Nature Physics, 2022 - nature.com
Quantum simulation has emerged as a valuable arena for demonstrating and understanding
the capabilities of near-term quantum computers 1 , 2 – 3 . Quantum annealing 4 , 5 has …

Quantum critical dynamics in a 5,000-qubit programmable spin glass

…, J Raymond, T Lanting, R Harris, A Zucca, F Altomare… - Nature, 2023 - nature.com
Experiments on disordered alloys 1 , 2 – 3 suggest that spin glasses can be brought into low-energy
states faster by annealing quantum fluctuations than by conventional thermal …

Architectural considerations in the design of a superconducting quantum annealing processor

…, E Tolkacheva, F Altomare… - IEEE Transactions …, 2014 - ieeexplore.ieee.org
We have developed a quantum annealing processor, based on an array of tunable coupled
rf-SQUID flux qubits, fabricated in a superconducting integrated circuit process. …

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

DA Altomare, HQ Wang, KL Skele, AD Rienzo… - Oncogene, 2004 - nature.com
Activation of the PI3K/AKT pathway may contribute to tumorigenesis. AKT mediates survival
signals that protect cells from apoptosis and, thus, is a potentially important therapeutic target…

Low-Dissipation Multiplexed Flux-Sensitive Readout in Superconducting Circuits

…, BH Eom, JD Whittaker, F Altomare… - 2015 15th …, 2015 - ieeexplore.ieee.org
D-Wave's quantum processors require a high-fidelity readout architecture for fast and
accurate operation. The need for cold operation precludes readout methods with significant …

[PDF][PDF] Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome

AC Paudel, JF Altomare, O Shogbesan, A Lee, P Desai… - Cureus, 2022 - cureus.com
Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and
portal vein. The majority of the cases are caused following liver transplant or hepatobiliary …