[HTML][HTML] Sequencing by avidity enables high accuracy with low reagent consumption
…, AH Mah, H Wang, J Zhao, C Zhou, A Altomare… - Nature …, 2024 - nature.com
We present avidity sequencing, a sequencing chemistry that separately optimizes the
processes of stepping along a DNA template and that of identifying each nucleotide within the …
processes of stepping along a DNA template and that of identifying each nucleotide within the …
[HTML][HTML] Viral activation and ecological restructuring characterize a microbiome axis of spaceflight-associated immune activation
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes, which play a role in some space-derived health disorders. …
modulating their microbiomes, which play a role in some space-derived health disorders. …
Characterizing and addressing error modes to improve sequencing accuracy
S Kruglyak, A Altomare, M Ambroso, V Dien, BR Lajoie… - bioRxiv, 2024 - biorxiv.org
The accuracy of a sequencing platform has traditionally been measured by the %Q30, or
percentage of data exceeding a basecall accuracy of 99.9%. Improvements to accuracy beyond …
percentage of data exceeding a basecall accuracy of 99.9%. Improvements to accuracy beyond …
Genome and Clonal Hematopoiesis Stability Contrasts with Immune, cfDNA, mitochondrial, and telomere length changes to Short Duration Spaceflight
The I4 mission, the first all-civilian orbital flight mission, investigated the physiological effects
of short duration spaceflight through a multi-omic approach. We analyzed telomere length, …
of short duration spaceflight through a multi-omic approach. We analyzed telomere length, …
Coherent quantum annealing in a programmable 2,000 qubit Ising chain
Quantum simulation has emerged as a valuable arena for demonstrating and understanding
the capabilities of near-term quantum computers 1 , 2 – 3 . Quantum annealing 4 , 5 has …
the capabilities of near-term quantum computers 1 , 2 – 3 . Quantum annealing 4 , 5 has …
Quantum critical dynamics in a 5,000-qubit programmable spin glass
Experiments on disordered alloys 1 , 2 – 3 suggest that spin glasses can be brought into low-energy
states faster by annealing quantum fluctuations than by conventional thermal …
states faster by annealing quantum fluctuations than by conventional thermal …
Architectural considerations in the design of a superconducting quantum annealing processor
…, E Tolkacheva, F Altomare… - IEEE Transactions …, 2014 - ieeexplore.ieee.org
We have developed a quantum annealing processor, based on an array of tunable coupled
rf-SQUID flux qubits, fabricated in a superconducting integrated circuit process. …
rf-SQUID flux qubits, fabricated in a superconducting integrated circuit process. …
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
DA Altomare, HQ Wang, KL Skele, AD Rienzo… - Oncogene, 2004 - nature.com
Activation of the PI3K/AKT pathway may contribute to tumorigenesis. AKT mediates survival
signals that protect cells from apoptosis and, thus, is a potentially important therapeutic target…
signals that protect cells from apoptosis and, thus, is a potentially important therapeutic target…
Low-Dissipation Multiplexed Flux-Sensitive Readout in Superconducting Circuits
…, BH Eom, JD Whittaker, F Altomare… - 2015 15th …, 2015 - ieeexplore.ieee.org
D-Wave's quantum processors require a high-fidelity readout architecture for fast and
accurate operation. The need for cold operation precludes readout methods with significant …
accurate operation. The need for cold operation precludes readout methods with significant …
[PDF][PDF] Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome
Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and
portal vein. The majority of the cases are caused following liver transplant or hepatobiliary …
portal vein. The majority of the cases are caused following liver transplant or hepatobiliary …