User profiles for Andrew Anand Brown
 | Andrew BrownPrincipal investigator, University of Dundee Verified email at dundee.ac.uk Cited by 12726 |
Fast and efficient QTL mapper for thousands of molecular phenotypes
Motivation: In order to discover quantitative trait loci, multi-dimensional genomic datasets
combining DNA-seq and ChiP-/RNA-seq require methods that rapidly correlate tens of …
combining DNA-seq and ChiP-/RNA-seq require methods that rapidly correlate tens of …
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
Understanding the genetic architecture of gene expression is an intermediate step in
understanding the genetic architecture of complex diseases. RNA sequencing technologies have …
understanding the genetic architecture of complex diseases. RNA sequencing technologies have …
Genetic interactions affecting human gene expression identified by variance association mapping
10.7554/eLife.01381.001 Non-additive interaction between genetic variants, or epistasis, is
a possible explanation for the gap between heritability of complex traits and the variation …
a possible explanation for the gap between heritability of complex traits and the variation …
Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues
Genetic association mapping produces statistical links between phenotypes and genomic
regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) …
regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) …
[HTML][HTML] CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls
Objectives Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar
disorder (BD) and schizophrenia (SZ) pathology. This polymorphism was recently found …
disorder (BD) and schizophrenia (SZ) pathology. This polymorphism was recently found …
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and …
BACKGROUND:: The Human Natural Killer-1 carbohydrate (HNK-1) is involved in
neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, …
neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, …
Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia
BACKGROUND: Because of evidence from genetic linkage and genome-wide association
studies, as well as suggested involvement of infection, the major histocompatibility complex (…
studies, as well as suggested involvement of infection, the major histocompatibility complex (…
Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study
OT Ousdal, AA Brown, J Jensen… - Twin research and …, 2012 - cambridge.org
As the amygdala is part of the phylogenetic old brain, and its anatomical and functional
properties are conserved across species, it is reasonable to assume genetic influence on its …
properties are conserved across species, it is reasonable to assume genetic influence on its …
Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis
Disrupted‐in‐Schizophrenia‐1 (DISC1) has been suggested as a susceptibility locus for a
broad spectrum of psychiatric disorders. Risk variants have been associated with brain …
broad spectrum of psychiatric disorders. Risk variants have been associated with brain …
Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways
Several lines of evidence suggest that common polygenic variation influences brain function
in humans. Combining high-density genetic markers with brain imaging techniques is …
in humans. Combining high-density genetic markers with brain imaging techniques is …