User profiles for Andrew Beggs

Andrew Beggs

Professor of Surgery & Cancer Genetics
Verified email at bham.ac.uk
Cited by 26761

[HTML][HTML] Nanopore sequencing and assembly of a human genome with ultra-long reads

…, AC Rand, TA Sasani, JR Tyson, AD Beggs… - Nature …, 2018 - nature.com
We report the sequencing and assembly of a reference genome for the human GM12878
Utah/Ceph cell line using the MinION (Oxford Nanopore Technologies) nanopore sequencer. …

Characteristics of early-onset vs late-onset colorectal cancer: a review

…, M Barussaud, A Bausys, B Bebington, A Beggs… - JAMA …, 2021 - jamanetwork.com
Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising
globally, the reasons for which are unclear. It appears to represent a unique disease process …

SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

…, AE Zielinska, M Crispin, DC Wraith, AD Beggs… - Thorax, 2020 - thorax.bmj.com
Objective To determine the rates of asymptomatic viral carriage and seroprevalence of
SARS-CoV-2 antibodies in healthcare workers. Design A cross-sectional study of asymptomatic …

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

…, A Chatzipli, C Hardy, CM Whalley, C Wu, AD Beggs… - Gut, 2021 - gut.bmj.com
Objective Complex phenotypes captured on histological slides represent the biological
processes at play in individual cancers, but the link to underlying molecular classification has not …

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

…, T Perry, A Beggs… - Blood, The Journal …, 2015 - ashpublications.org
Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and
children, yet significant numbers of patients relapse and die of disease. In this study, we identify …

[HTML][HTML] Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T cells targeted to vascular endothelium

…, M Ciaurriz, J Begum, N Lal, J Zuo, A Beggs… - PLoS …, 2016 - journals.plos.org
Cytomegalovirus (CMV) infection elicits a very strong and sustained intravascular T cell
immune response which may contribute towards development of accelerated immune …

Subtype-specific regulatory network rewiring in acute myeloid leukemia

…, SR James, J Zacarias-Cabeza, LN Gilding, A Beggs… - Nature …, 2019 - nature.com
Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations
in transcription factors, epigenetic regulators and signaling molecules. To determine how …

[HTML][HTML] Molecular characterization of colorectal cancer related peritoneal metastatic disease

…, JWM Martens, S Hallam, AD Beggs… - Nature …, 2022 - nature.com
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM)
in the course of their disease. PMs are associated with a poor quality of life, significant …

[HTML][HTML] COVID-19: Third dose booster vaccine effectiveness against breakthrough coronavirus infection, hospitalisations and death in patients with cancer: A …

…, MH Tuthill, I Watts, S Williams, A Beggs… - European Journal of …, 2022 - Elsevier
Purpose People living with cancer and haematological malignancies are at an increased
risk of hospitalisation and death following infection with acute respiratory syndrome …

KRAS mutation and consensus molecular subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer

…, G Goussous, O Pickles, MJ Mason, AD Beggs… - Clinical Cancer …, 2018 - AACR
Purpose: KRAS mutation is a common canonical mutation in colorectal cancer, found at
differing frequencies in all consensus molecular subtypes (CMS). The independent …