There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …

The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently
been shown to be capable of inducing immune upregulation and inhibition of pathogen …

Induction of antigen-specific CD8 + T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8 + T cells that correlate with …

The cellular and molecular mechanisms that underlie species-specific membrane fusion
between male and female gametes remain largely unknown. Here, by use of gene discovery …

As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop new …

Background Detection of the four malaria-causing Plasmodium species (Plasmodium falciparum,
Plasmodium vivax, Plasmodium ovale and Plasmodium malariae) within their mosquito …

The standard membrane feeding assay (SMFA) is currently considered to be the ‘gold standard’
for assessing the effectiveness of malaria transmission blocking interventions (TBIs) in …

Over a century since Ronald Ross discovered that malaria is caused by the bite of an
infectious mosquito it is still unclear how the number of parasites injected influences disease …

Fertilization in Plasmodium is a complex process that occurs in the gut of the female Anopheles
mosquito upon uptake of a bloodmeal. It requires the emergence of the gametocyte from …

Transmission-blocking interventions aim to reduce the prevalence of infection in endemic
communities by targeting Plasmodium within the insect host. Although many studies have …