User profiles for Andrew Chess
 | Andrew ChessProfessor of Cell, Developmental and Regenerative Biology and of Genetics and Geomic … Verified email at mssm.edu Cited by 13778 |
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network
BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains
a major scientific and medical challenge. Emerging genomic technologies now permit the …
a major scientific and medical challenge. Emerging genomic technologies now permit the …
Allelic inactivation regulates olfactory receptor gene expression
We suggest a model in which a hierarchy of controls is exerted on the family of odorant receptor
genes to assure that a sensory neuron expresses a single receptor from a family of 1000 …
genes to assure that a sensory neuron expresses a single receptor from a family of 1000 …
Mechanisms and consequences of widespread random monoallelic expression
A Chess - Nature Reviews Genetics, 2012 - nature.com
Although random monoallelic expression has been known for decades to affect genes on
the X chromosome in female placental mammals, until a few years ago it was thought that …
the X chromosome in female placental mammals, until a few years ago it was thought that …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
[PDF][PDF] An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles
NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20
large foci that we show are completely coincident with paraspeckles, nuclear domains …
large foci that we show are completely coincident with paraspeckles, nuclear domains …
[HTML][HTML] A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
…, CM Clemson, CR Lynch, JB Lawrence, A Chess - BMC genomics, 2007 - Springer
Background Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While
much recent attention has focused on smaller RNA species, larger noncoding transcripts are …
much recent attention has focused on smaller RNA species, larger noncoding transcripts are …
Gene body-specific methylation on the active X chromosome
A Hellman, A Chess - science, 2007 - science.org
Differential DNA methylation is important for the epigenetic regulation of gene expression.
Allele-specific methylation of the inactive X chromosome has been demonstrated at promoter …
Allele-specific methylation of the inactive X chromosome has been demonstrated at promoter …
Widespread monoallelic expression on human autosomes
Monoallelic expression with random choice between the maternal and paternal alleles
defines an unusual class of genes comprising X-inactivated genes and a few autosomal gene …
defines an unusual class of genes comprising X-inactivated genes and a few autosomal gene …
Monoallelic gene expression in mammals
A Chess - Annual Review of Genetics, 2016 - annualreviews.org
Monoallelic expression not due to cis-regulatory sequence polymorphism poses an intriguing
problem in epigenetics because it requires the unequal treatment of two segments of DNA …
problem in epigenetics because it requires the unequal treatment of two segments of DNA …
Identification of candidate Drosophila olfactory receptors from genomic DNA sequence
Q Gao, A Chess - Genomics, 1999 - Elsevier
We have taken advantage of the availability of a large amount of Drosophila genomic DNA
sequence in the Berkeley Drosophila Genome Project database (∼1/5 of the genome) to …
sequence in the Berkeley Drosophila Genome Project database (∼1/5 of the genome) to …