High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated
with interindividual blood pressure variation have been identified and replicated. Here we …

The interpretation of genome-wide association results is confounded by linkage disequilibrium
between nearby alleles. We have developed a flexible bioinformatics query tool for single-…

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS), including …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies
have identified common CKD susceptibility variants. The CKDGen consortium performed …

… Andrew D Johnson principal investigator84, Ron C Hoogeveen assistant professor of
medicine97, Hakon Hakonarson associate professor of paediatrics and director of genomics7, …

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum,
we conducted a meta-analysis of genome-wide association data from 26,676 T2D case …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …