Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior
and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and …

We interrogate the joint genetic architecture of 11 major psychiatric disorders at biobehavioral,
functional genomic and molecular genetic levels of analysis. We identify four broad …

Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted …

Little is known about the genetic architecture of traits affecting educational attainment other
than cognitive ability. We used genomic structural equation modeling and prior genome-wide …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta-…

Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause
considerable burden worldwide. Here we use factor analysis and genomic structural equation …

Self-regulation describes the ability to control both behaviors and internal states against a
backdrop of conflicting or distracting situations, drives, or impulses. In the cognitive …

It has been known since 1904 that, in humans, diverse cognitive traits are positively
intercorrelated. This forms the basis for the general factor of intelligence (g). Here, we directly test …